Breast problems and associated factors among lactating women in Northeast Ethiopia, 2022

Breastfeeding is the cornerstone of child and maternal health. However, maternal breast problems during breastfeeding have been frequently reported as one of the reasons for early discontinuation of breastfeeding. Despite the importance of having knowledge on breast problems magnitude and its associated factors in the clinical practices and designing effective interventions, there is limited data on this topic. Therefore, this study aimed to assess the prevalence and associated factors of breast problem among postnatal lactating women in Legambo district, south wollo zone, North East Ethiopia, in 2022. A community-based cross sectional study was conducted among 610 lactating mothers in Legambo district. Multi-stage sampling was employed to select study participants. Interviewer administered, WHO B-R-E-A-S-T-Feeding, observational checklist and maternal self-reported breast problem questionnaires were used to collect the data. Epi-Data version 3.1 was used for data entry and export to SPSS version 25.0 for analysis. Descriptive statistics and bi-variable and multivariable analysis was carried out. On the multivariable logistic regression, variables with p-value < 0.5 were considered as they had statistically significant association with breast problem. The overall prevalence of breast problems among postnatal lactating women was 54.3% (95%, CI 49.3–59.3%). Primipara (AOR = 5.09; 95% CI 3.40–7.62), preterm infant (AOR = 2.12; 95% CI 1.22–3.66), home delivery (AOR = 3.67; 95% CI 1.62–8.30), ineffective breastfeeding techniques (AOR = 2.45; 95%CI 1.61–3.74), caesarean section delivery (AOR = 2.05;95%CI :1.15–3.64) and mixed type of feeding (AOR = 1.97:95%CI 1.34–2.89) were factors showed significant association. The prevalence of breast problems was 54.3%. Relevant factors related to an increase risks are being primipara, cesarean section delivery, home delivery, preterm birth, ineffective breastfeeding techniques and mixed type of feeding.


Sample size determination
A single population proportion formula was used to calculate the sample size for this study with the assumption of a 95% confidence interval (CI), a margin of error of 5% and a 50% proportion.
Multi-stage was employed for sampling methods from district to kebeles and kebeles to house hold level, so sample size would be multiplied by 1.5, n = 384 * 1.5 = 576.
Considering 10% non-response rate, the total sample size was determined to be 634 postnatal mothers.

Sampling procedure
A multi-stage sampling method was used to select a representative sample.In the first stage, a simple random sampling technique was used to select eighteen kebeles from forty-one kebeles.From 38 rural kebeles, 16 kebeles were selected, and from the urban three kebeles, two kebeles were selected by simple random sampling.The number of women who delivered in each selected kebele was taken from the health extension worker's registration book.Then proportionally allocate the sample to each selected kebele.Finally, study participants were selected by simple random sampling by using the list of women in the extension worker registration book as a frame.

Variables
Dependent variable Breast problem.

Independent variables
Socio-demographic age, educational status, residence, marital status and occupation of the mother.

Data collection tools and procedure
The data were collected by using interviewer-administered questionnaires, an observational checklist, and maternal self-reported signs and symptoms of breast problems.The questionnaires included socio-demographic, obstetrical, breastfeeding, maternal healthcare, and breast problem-related characteristics.An observational checklist, based on the World Health Organization (WHO) B-R-E-A-S-T-Feeding observation form 23 , was used to assess mother and baby's position; attachment, and suckling during breastfeeding.This form was developed by the WHO and United Nations Children's Fund (UNICEF) to suit for low resource settings 24 .The tool were developed and modified from relevant studies 22,[25][26][27][28] .Interviewer-administered questionnaires were initially prepared in English and then translated into the local language (Amharic) by language experts.To evaluate positioning, attachment, and suckling during breastfeeding, an arbitrary scoring and grading system was adopted and developed based on WHO criteria 12 , with each criterion assigned a value (Table 1).
Ten trained female midwives with Bachelor's degrees (BSc.)collected the data after receiving training through video demonstrations and hands-on practice.The data collectors observed breastfeeding practices for four minutes and recorded the positioning, attachment, and suckling using the WHO B-R-E-A-S-T-Feeding observation checklist form 23 .Postnatal lactating mothers were approached, their willingness to participate in the study was assessed, and interviews and observations were conducted only after obtaining written consent.

Data quality control
To assure data quality, both the data collectors and supervisors received a 2-day training covering the study's objectives, relevance, expected challenges and difficulties, confidentiality of information, respondents' rights, informed consent, and interview techniques.A pretest was conducted in Dessie Zuria involving 5% (32 women) of the total sample size, before the actual data collection period.This was aimed to assess the instrument simplicity, flow, and consistency, as well as to check the instrument's reliability.The overall reliability, measured by Cronbach alpha, was found to be 0.78.Each questionnaire was checked for completeness and unlikely responses prior to data entry.The data were then edited, coded, and entered into Epi Data version 3.1.Two data clerks performed double data entry, and entry errors were checked and corrected by referring back to the questionnaires.

Data processing and analysis
Data clerks and the supervisor visually checked for completeness before being coded and entered into the computer using Epi-Data version 3.1.During the analysis process using SPSS version 25.0, descriptive statistics were performed on each variable, and the results were presented in tables, figures, and texts using summary measures such as percentage, mean, and standard deviation.Bivariable logistic regression was conducted, and variables with p-values less than 0.25 were included in the multivariable logistic regression to examine the relative effect of the confounding variable and variable interaction.Variables with a p-value of 0.05 were considered statistically significant in multivariable logistic regression analysis.The omnibus test of model coefficients and Hosmer and Lemeshow goodness-of-fit test were used to assess the overall model summary and model goodness of fit, respectively, yielding values of 0.000 and 0.834, respectively.The variance inflation factor (VIF) and tolerance test were used to check for multicollinearity among the explanatory variables, with the highest VIF being 1.16 and the lowest tolerance test being 86%.

Ethics approval and consent to participate
Ethical clearance was obtained from the Wollo University College of Medicine and Health Sciences Ethical Review Board (Ref.No CMHS/004/13).The study was conducted in adherence to the Declaration of Helsinki and relevant guidelines and regulations.Written informed consent was received from all participants prior to actual data collection.

Socio-demographic characteristics of the study participants
From the 634 study participants, 610 lactating mothers were observed for breast problems and interviewed, giving a response rate of 96.2%.About 278 (45.6%) of mothers were in the age group of 20-25 years, and the mean age of the study participants was 25.69 years, with SD ± 6.014 years.The majority of the respondents were housewives and rural dwellers, 77.2% and 53.6%, respectively.Near to Ninety percent of the respondents (89.3%) were married.Regarding their level of education, 266 (43.6%) had no formal education (Table 1).

Obstetrics characteristic of the respondents
Of the total participants, 380 (62.3%) were multipara and 56 (9.2%) gave birth at home.Regarding mode of delivery, 517 (84.8%) were give births by spontaneous vaginal deliveries.Of 534 (87.5%), infants were born at term gestational age and 554 (90.8%) of postpartum women had no previous breast problem history (Table 2).

Breastfeeding characteristics of the study participants
Of the total participants 236 (61.3%) of postnatal lactating mother were give prelacteal feed for their infant and only 74 (12.1%) of postnatal lactating mother were initiated breastfeeding within one hour of delivery.Of the total participants around frothy percent (38.2%) of postnatal lactating mothers mixed feed their infants with other food and fluid in addition to breast milk at the time of the interview.More than seventy four percent (74.18 percentage) of the mother practiced ineffective breastfeeding techniques (Table 3).

Maternal and health care system characteristic
Around seventy five percent 456 (74.8%) of the study participants had antenatal care (ANC) follow up.More than 80 percent (81.97%) of mothers received postnatal care.Just over fifty five percent 341 (55.9%) of the study participants had received information about breastfeeding from their friends and family.Regarding their breastfeeding experience 295 (48.4%) of postnatal women had previous experience.Out of 610 mothers, 346 (56.7%) had good knowledge on the benefits of breastfeeding for maternal and child health (Table 4).

Individual breast problem sign and symptoms
The commonest self-reported symptoms of breast problems were pain (55.7%), difficulty of milking or difficulty to feed and attach breast (47.5%) (Table 5).

Factors associated with breast problems
In the bi-variable logistic regression analysis, eleven variables had p-values less than 0.  www.nature.com/scientificreports/delivery, previous breast problem history, pre-lacteal feeding, breastfeeding experience, breastfeeding technique and type of feeding).Home delivery, primipara, preterm infants, cesarean delivery, ineffective breastfeeding technique and mixed type of feeding were identified as having a significantly association with breast problems on the multivariable analysis.This study identified that the odds of breast problem was 3.67 times (AOR = 3.67; 95% CI 1.62, 8.30) higher among women who give birth at home than health institutions.Similarly, the odds in primipara were 5.09 times Additionally, the odds of breast problem among women who delivered by caesarean section were 2.45 times (AOR = 2.45; 95% CI 1.61-3.74)higher as compared with vaginal delivery, and the odds was 1.55 times (AOR = 1.55; 95% CI 1.07, 2.25) times higher among women who practice ineffective breastfeeding techniques than effective breastfeeding techniques.Moreover, the odds of breast problem in women who provide mixed feed were 1.97 times (AOR = 1.97:95%CI 1.34, 2.89) higher than women who feed breast milk exclusively (Table 6).

Discussion
This study identified that the prevalence of breast problems in the district during postnatal period was 54.3% (95% CI 49.3-59.3%).Among these problems, breast engorgement was the most common (36.1%), followed by cracked nipple, mastitis, inverted nipple, flat nipple, and abscess (12.6%, 10.0%, 4.90%, 2.10%, and 2.00% respectively).However, a study conducted in Iran showed that the breast fissure as the most common breast problem followed by inverted nipples and mastitis 29 .A study conducted in Egypt reported a prevalence of 82% 30 and in India it ranges from 65 to 75% 31 , which is higher than the finding of the current study.Conversely, the current study's results were higher than studies conducted in United States 9.5% 32 , South Asia 8% 25 , India (5.1%) 33 , and Australia 20% 26 .These differences might be due to variations in the study design, inclusion criteria, and sampling methods.
The current study's findings are in line with studies conducted in Egypt (Tanta and Helwan university) where more than half of the mothers (54.6%) developed postpartum breast problems 16 .This study's findings are also consistent with a study conducted in Bangladesh, which reported rates of 7.89%, 2.63%, and 1.75%) 2 for cracked, inverted, and flat nipple respectively.Additionally, the abscess rate in Egypt (Tanta) was (2.75%) 3 , and in Egypt (Zagazig University) it was (1.28%) 15 , which are similar to the findings of this study.
Primiparous women were more likely than multiparous to develop breast problems.This finding is supported by a study conducted in India 3 .The possible explanation for this is that multiparous women have a higher degree of awareness of breast problems in the first 3 days after birth compared to primiparous women.Primigravida women are also at a higher risk of labor complications, which can result in cesarean delivery and a lower likelihood of timely initiation of breastfeeding.Additionally, primiparous mothers may have poorer attachment and positioning practices compared to multiparous women 25 , and multiparous women are more likely to have knowledge of childcare and feeding techniques from their previous child.www.nature.com/scientificreports/Women with preterm infants had higher odds of developing breast problems compared to mothers with term infants.This finding is supported by a study conducted in Texas 27 .This difference might be due to restrictions on mother-infant continuous contact in neonatal intensive care units, as well as delays in discharge and limited contact with the mother after overcoming complications such as intraventricular hemorrhage and necrotizing enterocolitis.Preterm infants may also have difficulty successfully suckling breast milk compared to full-term infants, as supported by a study conducted in Bangladesh 22 .Additionally, the younger age of preterm newborns contributes to their limited physical maturity and physiological functioning, which delays their ability to attach to the breast properly 12 .
Women who delivered by caesarean section were more likely to develop breast problems compared to those who had spontaneous vaginal delivery.This finding is supported by studies conducted in many countries 2,23,[34][35][36] .The possible explanation might be the adverse association between cesarean section and breastfeeding.Postoperative care routines may interrupt the onset of lactation, disturb mother-infant interaction, and inhibit infant suckling.Mothers who undergo cesarean section might be under the effect of anesthesia for extended periods after the operation, which can prevent from regular emptying of the breasts and increase the risk of milk stasis and breast problems.Additionally, the immediate postpartum period is challenging for mothers who have undergone cesarean delivery due to pain, which can affect their ability to breastfeed early and contribute to breast problems.
Women who gave birth at home had higher odds of developing breast problems compared to those who gave birth at a health institution.This finding is supported by a study conducted in Bangladeshi 6 .This might be due to the lack of counseling and support received by women who deliver at home, as they may not have access to breastfeeding, attachment, and positioning guidance.In contrast, women who give birth at health institutions are more likely to receive counseling services and initiate breastfeeding early.
Women who practice ineffective breastfeeding were more likely to develop breast problems than those who practice effective breastfeeding techniques.This finding is supported by a study conducted in Brazil 26 .Poor positioning, attachment, weak or uncoordinated suckling, and incorrect handling of the infant at the mother's breast can lead to nipple trauma and contribute to the development of breast problems.Furthermore, inefficient removal of breast milk can lead to milk stagnation and engorgement, making attachment and suckling more challenging.This can progress to more severe forms of breast problems such as mastitis and abscess 1 .
Women who supplement with mixed foods and fluids for infants were more likely to develop breast problems than those who exclusively breastfed.This might be due to the intake of additional food and liquids reducing the frequency and duration of breastfeeding, leading to inadequate breast emptying and increased risk of breast problems.Moreover, this practice increases the risk for the development of illnesses, such as pneumonia or diarrhea, which affects some aspects of the sucking technique and regular breast milk emptying 3,25 .
This study has certain limitations that should be considered when interpreting the results.Firstly, the use of interviewer-administered questions might introduce recall bias.Additionally, the Hawthorne effect might present while trying to use the observational checklist.However, attempts were made to minimize this effect by concealing the observation from the study participants.

Conclusion
The study revealed a prevalence rate of 54.3% for breast problems during the postnatal period.Parity, mode of delivery, place of delivery, preterm birth, ineffective breastfeeding techniques, and mixed feeding were identified as significant factors associated with these problems.Given that breast problems can lead to adverse effects like feeding difficulties, decreased milk supply, compromised emotional bonding, and suboptimal weight gain for the child, as well as chronic inflammation and associated non-breastfeeding can also increase future risk of developing breast cancer.Therefore, it is imperative to address, prevent, and manage breast problems effectively, and ensuring access to quality healthcare services with appropriate health professional mix.Health care providers and researchers can also tailor interventions and support strategies accordingly. https://doi.org/10.1038/s41598-024-58957-0

Table 1 .
Socio-demographic characteristics of the participants for the study conducted in Legambo district, north east Ethiopia, 2022 (n = 610).Others a : widowed and divorced.

Table 2 .
Obstetrics characteristics of the participants for the study conducted in Legambo district, north east Ethiopia, 2022 (n = 610).SVD spontaneous vaginal delivery, CS cesarean delivery, GA gestational age.
25 and were entered into multivariable logistic regression (occupation, age of mothers, place of birth, parity, gestational age, mode of

Table 3 .
Breastfeeding characteristics of the participants for the study conducted in Legambo district, north east Ethiopia, 2022 (n = 610).

Table 4 .
Maternal and health care characteristics of the study participants for the study conducted in Legambo district, north east Ethiopia, 2022 (n = 610).Audio visual a -radio, TV, Newspaper and internet.